To understand antibiotic resistance, Vergalli et al. quantify intracellular accumulation of 2 fluoroquinolones in E. coli cells expressing different levels of the AcrB multidrug efflux pumps. Their 3 study highlights the role of the molecular/structural dialogue between a drug family and the affinity 4 sites of membrane transporters.
- Julia Vergalli
- Alessio Atzori
- Jean-Marie Pagès
