Nature Search

A renewable and socially accepted energy system for astronomical telescopes

Telescopes around the world are usually built in remote areas to maximize observational effectiveness, usually relying on fossil fuel-based energy generators for their operations. This Article analyses community involvement in designing an energy system for a telescope in the Atacama Desert that is both environmentally sustainable and inclusive.

Guillermo Valenzuela-Venegas
Maria Luisa Lode
Marianne Zeyringer
Research11 Oct 2024
Nature Sustainability

Volume: 7, P: 1642-1650
Spatiotemporal expression and control of haemoglobin in space

Here the authors analyse the impact of space on haemoglobin gene regulation using data from NASA, JAXA and SpaceX i4 missions. They find that globin gene down-regulation leads to space anaemia with post-flight recovery, and reveal an adult-to-foetal globin switch activation.

Josef Borg
Conor Loy
Joseph Borg
ResearchOpen Access11 Jun 2024
Nature Communications

Volume: 15, P: 1-15
Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

Sjaak Philipsen and colleagues report that haploinsufficiency for KLF1 causes hereditary persistence of fetal hemoglobin in a large Maltese family. They further show that KLF1 is a key activator of BCL11A, which suppresses the expression of fetal hemoglobin.

Joseph Borg
Petros Papadopoulos
Sjaak Philipsen
Research01 Aug 2010
Nature Genetics

Volume: 42, P: 801-805
Neoantigen-directed immune escape in lung cancer evolution

RNA sequencing data and tumour pathology observations of non-small-cell lung cancers indicate that the immune cell microenvironment exerts strong evolutionary selection pressures that shape the immune-evasion capacity of tumours.

Rachel Rosenthal
Elizabeth Larose Cadieux
Andrew Kidd
Research20 Mar 2019
Nature

Volume: 567, P: 479-485
Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach

George Patrinos and colleagues report the first implementation of the microattribution approach to systematically document genetic variation associated with a disease, applied here to hemoglobinopathies and thalassemias. They developed a series of connected locus-specific databases that document genotype and phenotype information for genetic variation in 37 globin and erythroid protein genes in individuals with globin disorders, with reciprocal attribution to data contributors.

Belinda Giardine
Joseph Borg
George P Patrinos
ResearchOpen Access20 Mar 2011
Nature Genetics

Volume: 43, P: 295-301
The EuroBioBank Network: 10 years of hands-on experience of collaborative, transnational biobanking for rare diseases

Marina Mora
Corrado Angelini
Hanns Lochmüller
ReviewsOpen Access24 Dec 2014
European Journal of Human Genetics

Volume: 23, P: 1116-1123
Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts

Steven Heshusius
Laura Grech
Sjaak Philipsen
ResearchOpen Access10 Jan 2022
Scientific Reports

Volume: 12, P: 1-11

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A renewable and socially accepted energy system for astronomical telescopes

Spatiotemporal expression and control of haemoglobin in space

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

Neoantigen-directed immune escape in lung cancer evolution

Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach

The EuroBioBank Network: 10 years of hands-on experience of collaborative, transnational biobanking for rare diseases

Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts

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A renewable and socially accepted energy system for astronomical telescopes

Spatiotemporal expression and control of haemoglobin in space

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

Neoantigen-directed immune escape in lung cancer evolution

Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach

The EuroBioBank Network: 10 years of hands-on experience of collaborative, transnational biobanking for rare diseases

Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts

Search

Quick links