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Showing 1–6 of 6 results
Advanced filters: Author: Alex Kleinpeter Clear advanced filters

  • IP6 is a critical host cofactor for HIV-1 assembly and infectivity. In this study, the authors uncover the structural basis by which HIV-1 adapts to a deficiency in IP6 packaging through a G225R mutation at the C-terminus of the capsid protein.

    • Yanan Zhu
    • Alex B. Kleinpeter
    • Peijun Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Renner et al. show that HIV-1 concentrates the metabolite IP6 into its virions to catalyze assembly of its iconic conical capsid. Disabling this enrichment mechanism prevents assembly and renders HIV-1 non-infectious.

    • Nadine Renner
    • Alex Kleinpeter
    • Leo C. James
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 370-382

  • HIV maturation inhibitors such as bevirimat (BVM) interfering with Gag processing are emerging as alternative anti-retroviral drug candidates. Here, the authors report structures of assemblies of HIV-1 Gag fragments spanning the CA C-terminal domain and SP1 region bound to BVM.

    • Sucharita Sarkar
    • Kaneil K. Zadrozny
    • Tatyana Polenova
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Mendonça et al. determine the structures of both in vitro assemblies of the HIV structural precursor protein Gag and Gag viral-like particles (VLPs) to 4.2 Å and 4.5 Å resolutions, using cryo-electron tomography and subtomogram averaging. This study provides insights into the future development of small molecule inhibitors for HIV-1 infection.

    • Luiza Mendonça
    • Dapeng Sun
    • Peijun Zhang
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-9