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The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

A multi-ancestry meta-regression study analyses diverse genome-wide association studies and genome loci associated with tobacco and alcohol use.

Repetitive shallow resonances provide a pathway to unravelling episodic magma transport deep in the magma plumbing system. Episodic deformation of ~1 nanoradian over ~100 s beneath Aso volcano potentially provides a link between long-term volcanic output and short-term eruption dynamics.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

The authors show that changes in nuclear dynamics of p75^NTR by γ-secretase cleavage are a novel molecular switch that determines TGF-β signaling in astrocytes. Cleaved p75^NTR acts as a component of the nuclear pore complex, regulating nuclear import of Smad-2 in astrocytes. The authors find that p75^NTR is required in mice for TGF-β-induced glial scar formation and reduced neuronal activity.

The authors report that tensile strain applied to CsV₃Sb₅ strongly suppresses the charge-density-wave (CDW) gap, increases the mass of the fermions at the higher-order van Hove singularity (HO-VHS) and drives the energy of the HO-VHS towards the Fermi energy. Further, they suggest an important role of the HO-VHS in superconducting pairing.

Urban income segregation is often discussed in terms of where people live. Here, the authors show that the way people experience income segregation is also associated with their mobility patterns and the places they visit.

Newly emerged pathogens are inherently difficult to forecast, due to many unknowns about their biology early in an epidemic. Here, the authors assess forecasts of a suite of models during the Zika epidemic in Colombia, finding that the models that performed best changed over the course of the epidemic.

A method for comorbidity discovery informed by each patient’s demographic and medical history is introduced. Statistics for 4,623,841 pairs of potentially comorbid medical terms are provided as a searchable web resource.

A study establishes a scalable approach to engineer and characterize a many-body-localized discrete time crystal phase on a superconducting quantum processor.

SARS-CoV-2 constantly evolves but the roles of resulting mutations are not always clear. In this study, the authors report that ORF8 knockout confers a fitness advantage to SARS-CoV-2 using genomic surveillance data, highlighting how different types of adaptations across the SARS-CoV-2 genome can drive variant fitness.

Post-translational modification of microtubules by detyrosination is prevalent in failing human cardiomyocytes and inhibits cardiomyocyte contraction, suggesting a new therapeutic strategy for improving heart function.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

By combining theory and empirical data, the authors show that the adaptive capacity of arthropod populations to long-term climatic warming will be constrained by the temperatures at which the performance of four key life-history traits can peak.

A hybrid model combines quantum and classical approaches to generate compounds targeting the KRAS protein.

Link damages and failures can break the functionality of the whole complex network. Inspired by biological systems that respond to damages, the authors propose a mathematical model revealing the effect of homeostatic response to damage of links to keep the network’s global function.

Guiding the assembly pathway of a nanoparticle system toward multiple superstructures while visualizing in situ remains challenging. Here the authors combine liquid-cell transmission electron microscopy, scaling theory and molecular dynamics simulations to image and quantify self-assembly processes of gold nanocubes into distinct superlattices.

Recent improvements in the indirect-drive inertial confinement fusion experiments include the achievement of burning plasma state. Here the authors report the scaling of neutron yield in a burning plasma of Deuterium-Tritium fusion reaction by including the mode-2 asymmetry.

Transcriptomic analyses of acute phase whole blood from a large cohort of patients with COVID-19 identify molecular determinants of post-infection long-term sequelae.

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

Production of male and female forms of the malaria parasite in an infected person is crucial for transmission of the disease. Here, Tran et al.show that an ABC transporter protein of the parasite, expressed in the female cells, modulates lipid accumulation and formation of sexual cells.

Lowering the levels of disease-promoting proteins is generally assumed to be beneficial. The authors developed a two-step strategy to integrate protein-level tuning, noise-aware synthetic gene circuits into a well-defined human genomic locus. This approach was used to study the effect of BACH1 levels on MDA-MB-231 human breast metastatic cells.

The giant planet 8 Ursae Minoris b seems to have avoided engulfment by its giant host star through a stellar merger that either affected the evolution of the host star or produced 8 Ursae Minoris b as a second-generation planet.

Being man’s best friend, dogs have been bred and selected for certain morphologic traits and breed-associated behaviours. Here, Plassais et al. analyse 722 canine whole genome sequences including modern breeds, wild canids and village dogs by GWAS and search for signatures of selection.

Mobile phone data reveals a significant decrease in the income diversity of urban encounters during the COVID-19 pandemic in the USA, even though overall mobility returned to pre-pandemic levels by late 2021. This was mainly due to persistent behavioral changes including less willingness to explore new places.

Two-dimensional materials offer the prospect of excitonic devices operating at room-temperature. Here, Kleemann et al. demonstrate that by tuning the number of WSe₂ layers in a nanoparticle-on-mirror geometry, room-temperature plasmon strong-coupling can be achieved with large Rabi splittings.

Michael Talkowski and colleagues analyze balanced chromosomal abnormalities in 273 individuals by whole-genome sequencing. Their findings suggest that sequence-level resolution improves prediction of clinical outcomes for balanced rearrangements and provides insight into pathogenic mechanisms such as altered gene regulation due to changes in chromosome topology.

Measuring rhythm priors in 39 participant groups from 15 countries, the authors find that properties of rhythm representations are common across cultures, while variation from place to place related to local musical traditions exists.

The authors develop a method to measure the coupling between a single photon source and any arbitrary photonic structure having constant density of electromagnetic states over the linewidth of the emitter. They demonstrate this method by an experiment on a single molecule coupled to an interrupted nanophotonic waveguide.

Genetic code redundancies are considered inconsequential to protein structure. This study uncovers a dependence between local amino acid conformation in folded proteins and the identity of the codon from which that amino acid was translated.

Data from over 700,000 individuals reveal the identity of 83 sequence variants that affect human height, implicating new candidate genes and pathways as being involved in growth.

Fanni Gergely, Geoffrey Woods and colleagues identify a disease-associated CEP63 mutation in a family with primary microcephaly. They further show that CEP63 and CEP152 interact and form a discrete ring around the proximal end of the parental centriole, implicating this complex in the regulation of centrosome number.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

JWST–NIRSpec spectroscopic confirmation of two luminous galaxies is presented, proving that luminous galaxies were already in place 300 million years after the Big Bang and are more common than what was expected before JWST.

Physical realizations of qubits are often vulnerable to leakage errors, where the system ends up outside the basis used to store quantum information. A leakage removal protocol can suppress the impact of leakage on quantum error-correcting codes.

The process of protein crystallization is poorly understood and difficult to program through the primary sequence. Here the authors develop a computational approach to designing three-dimensional protein crystals with prespecified lattice architectures with high accuracy.