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Showing 1–2 of 2 results
Advanced filters: Author: Alex Sloutsky Clear advanced filters

  • Resistance to antibiotics hampers the treatment of infectious diseases such as tuberculosis (TB). Here, Farhat et al. perform genome-wide association testing for minimum inhibitory concentration (MIC) of 12 anti-TB drugs in whole-genome sequenced clinical M. tuberculosis isolates and identify 13 genomic loci.

    • Maha R. Farhat
    • Luca Freschi
    • Megan Murray
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Maha Farhat, Megan Murray and colleagues report whole-genome sequencing of 116 Mycobacterium tuberculosis strains selected to be representative of both global diversity and drug resistance. The authors develop a new method to search for resistance markers in microbial genomes based on reconstructing a genome-wide phylogeny and identifying regions showing convergent evolution, and they use this method to identify 39 new candidate drug resistance regions in the M. tuberculosis genome.

    • Maha R Farhat
    • B Jesse Shapiro
    • Megan Murray
    Research
    Nature Genetics
    Volume: 45, P: 1183-1189