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Showing 1–5 of 5 results
Advanced filters: Author: Alex Virasami Clear advanced filters

  • Senescent cells increase with ageing and may cause inflammatory conditions, but how this accumulation is mediated is still unclear. Here the authors show that senescent cells express HLA-E to suppress NKG2A-mediated natural killer and CD8 T cell activation to avoid targeted elimination, while blocking NKG2A helps promote immunity against senescent cells.

    • Branca I. Pereira
    • Oliver P. Devine
    • Arne N. Akbar
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Patients with mutations in the ASL gene present with argininosuccinic aciduria characterised by hyperammonaemia and cognitive impairment. Here, the authors show that cerebral disease involves neuronal nitrosative/oxidative stress that is not induced by hyperammonaemia, and that it can be reversed using AAV-ASL directed to liver and brain in mice.

    • Julien Baruteau
    • Dany P. Perocheau
    • Simon N. Waddington
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Senescent cells can promote tumour progression through the activation of a senescenceassociated secretory phenotype (SASP). Here, the authors show that SASP activation is associated with non-cell autonomous cell transformation and tumour initiation in an in vivo model of adamantinomatous craniopharyngioma.

    • Jose Mario Gonzalez-Meljem
    • Scott Haston
    • Juan Pedro Martinez-Barbera
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14