Nature Search

Role of NF-κB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death

Alexander Arlt
Andre Gehrz
Heiner Schäfer
Research22 May 2003
Oncogene

Volume: 22, P: 3243-3251
Painting with light-powered bacteria

The ability to generate microscale patterns and control microswimmers may be useful for engineering smart materials. Here Arlt et al. use genetically modified bacteria with fast response to changes in light intensity to produce light-induced patterns.

Jochen Arlt
Vincent A. Martinez
Wilson C. K. Poon
ResearchOpen Access22 Feb 2018
Nature Communications

Volume: 9, P: 1-7
The early response gene IEX-1 attenuates NF-κB activation in 293 cells, a possible counter-regulatory process leading to enhanced cell death

Alexander Arlt
Marie-Luise Kruse
Heiner Schäfer
Research22 May 2003
Oncogene

Volume: 22, P: 3343-3351
Automated discovery of experimental designs in super-resolution microscopy with XLuminA

Researchers have developed XLuminA, an AI framework for the automated discovery of super-resolution microscopy techniques. With 10,000x faster optimization than traditional methods, it discovers unexplored designs breaking the diffraction limit.

Carla Rodríguez
Sören Arlt
Mario Krenn
ResearchOpen Access10 Dec 2024
Nature Communications

Volume: 15, P: 1-14
Evidence the Isc iron–sulfur cluster biogenesis machinery is the source of iron for [NiFe]-cofactor biosynthesis in Escherichia coli

Alexander Haase
Christian Arlt
R. Gary Sawers
ResearchOpen Access06 Feb 2024
Scientific Reports

Volume: 14, P: 1-13
Dynamics-dependent density distribution in active suspensions

It has been predicted theoretically that the density of self-propelled particles whose speed is spatially dependent should be inversely proportional to the local speed. Here the authors present a systematic check of this prediction in a system of light-activated E. coli.

Jochen Arlt
Vincent A. Martinez
Wilson C. K. Poon
ResearchOpen Access24 May 2019
Nature Communications

Volume: 10, P: 1-7
[¹¹C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial

Comparison of non-invasive [¹¹C]metomidate PET-CT with adrenal vein sampling for predicting biochemical remission of primary aldosteronism showed non-superiority, suggesting that the non-invasive method is suitable for the diagnosis of unilateral primary aldosteronism.

Xilin Wu
Russell Senanayake
Morris J. Brown
ResearchOpen Access16 Jan 2023
Nature Medicine

Volume: 29, P: 190-202
Hepatitis B virus–induced lipid alterations contribute to natural killer T cell–dependent protective immunity

Hepatitis B virus (HBV) infection is known to be controlled by T and B cell responses, but the role of natural killer T (NKT) cells is less clear. Richard Blumberg and his colleagues now show that NKT cells are activated immediately after HBV infection by presentation of an HBV-altered repertoire of lysophospholipids on infected hepatocytes and are necessary for the induction of optimal T and B cell responses and rapid viral control.

Sebastian Zeissig
Kazumoto Murata
Richard S Blumberg
Research17 Jun 2012
Nature Medicine

Volume: 18, P: 1060-1068
Identification and characterization of two functional variants in the human longevity gene FOXO3

FOXO3 is one of the few established longevity genes. Here, the authors fine-map the FOXO3-longevity association to two intronic SNPs and, using luciferase assays and EMSAs, show that these SNPs affect binding of transcription factors CTCF and SRF and associate with FOXO3 expression.

Friederike Flachsbart
Janina Dose
Almut Nebel
ResearchOpen Access12 Dec 2017
Nature Communications

Volume: 8, P: 1-12
Epithelial calcineurin controls microbiota-dependent intestinal tumor development

The intestinal microbiota signals through epithelial cells to activate calcineurin and NFAT, driving proliferation of cancer stem cells and the development of colorectal cancer.

Kenneth Peuker
Stefanie Muff
Sebastian Zeissig
Research04 Apr 2016
Nature Medicine

Volume: 22, P: 506-515
Publisher Correction: Identification and characterization of two functional variants in the human longevity gene FOXO3

Friederike Flachsbart
Janina Dose
Almut Nebel
Amendments and CorrectionsOpen Access17 Jan 2018
Nature Communications

Volume: 9, P: 1-2
Serum anti-NMDA receptor antibodies are linked to memory impairment 12 months after stroke

Friederike A. Arlt
Pia S. Sperber
Peter Bartenstein
ResearchOpen Access30 Oct 2024
Molecular Psychiatry

Volume: 30, P: 1359-1368
Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair

By studying a severe neuropathy in mice, Quintes, Brinkmann et al. demonstrate that the nuclear zinc-finger protein Zeb2 (Sip1) is essential for Schwann cell differentiation and myelin synthesis. Since Zeb2-deficient Schwann cells continuously express repressors of lineage progression, ‘inhibiting the inhibitors’ emerges as a new principle of peripheral myelination control.

Susanne Quintes
Bastian G Brinkmann
Klaus-Armin Nave
Research01 Aug 2016
Nature Neuroscience

Volume: 19, P: 1050-1059
Species delimitation and mitonuclear discordance within a species complex of biting midges

Phillip Shults
Matthew Hopken
Edward L. Vargo
ResearchOpen Access02 Feb 2022
Scientific Reports

Volume: 12, P: 1-13
NF-κB/RelA controlled A20 limits TRAIL-induced apoptosis in pancreatic cancer

Claudia Geismann
Charlotte Hauser
Alexander Arlt
ResearchOpen Access03 Jan 2023
Cell Death & Disease

Volume: 14, P: 1-10
Postoperative bioactive adrenomedullin is associated with the onset of ARDS and adverse outcomes in patients undergoing open thoracoabdominal aortic surgery

Panagiotis Doukas
Oliver Hartmann
Alexander Gombert
ResearchOpen Access04 Jun 2024
Scientific Reports

Volume: 14, P: 1-10
Expression of the NF-κB target gene IEX-1 (p22/PRG1) does not prevent cell death but instead triggers apoptosis in Hela cells

Alexander Arlt
Olaf Grobe
Heiner Schäfer
Research17 Jan 2001
Oncogene

Volume: 20, P: 69-76
Inhibition of NF-κB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin

Alexander Arlt
Jens Vorndamm
Heiner Schäfer
Research09 Apr 2001
Oncogene

Volume: 20, P: 859-868
Correction: Inhibition of NF-κB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin

Alexander Arlt
Jens Vorndamm
Heiner Schäfer
Amendments and Corrections18 Apr 2002
Oncogene

Volume: 21, P: 2611
The antioxidant transcription factor Nrf2 modulates the stress response and phenotype of malignant as well as premalignant pancreatic ductal epithelial cells by inducing expression of the ATF3 splicing variant ΔZip2

My-Lan Kha
Lisa Hesse
Heiner Schäfer
Research09 Oct 2018
Oncogene

Volume: 38, P: 1461-1476
Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes

A human Cytokimera GIL-11 is generated, with specific high affinity activation of the non-natural receptor gp130:LIFR:IL-11R complex and can rescue IL-6R deficient mice from death following partial hepatectomy.

Puyan Rafii
Christiane Seibel
Jürgen Scheller
ResearchOpen Access15 Apr 2023
Communications Biology

Volume: 6, P: 1-14
Native mass spectrometry identifies the HybG chaperone as carrier of the Fe(CN)₂CO group during maturation of E. coli [NiFe]-hydrogenase 2

Christian Arlt
Kerstin Nutschan
R. Gary Sawers
ResearchOpen Access21 Dec 2021
Scientific Reports

Volume: 11, P: 1-12
MTOR inhibitor-based combination therapies for pancreatic cancer

Zonera Hassan
Christian Schneeweis
Günter Schneider
ResearchOpen Access02 Jan 2018
British Journal of Cancer

Volume: 118, P: 366-377
PKCμ prevents CD95-mediated apoptosis and enhances proliferation in pancreatic tumour cells

Anna Trauzold
Stefan Schmiedel
Holger Kalthoff
Research04 Dec 2003
Oncogene

Volume: 22, P: 8939-8947
CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-κB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells

Anna Trauzold
Hendrik Wermann
Holger Kalthoff
Research17 Jul 2001
Oncogene

Volume: 20, P: 4258-4269

Search

Role of NF-κB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death

Painting with light-powered bacteria

The early response gene IEX-1 attenuates NF-κB activation in 293 cells, a possible counter-regulatory process leading to enhanced cell death

Automated discovery of experimental designs in super-resolution microscopy with XLuminA

Evidence the Isc iron–sulfur cluster biogenesis machinery is the source of iron for [NiFe]-cofactor biosynthesis in Escherichia coli

Dynamics-dependent density distribution in active suspensions

[¹¹C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial

Hepatitis B virus–induced lipid alterations contribute to natural killer T cell–dependent protective immunity

Identification and characterization of two functional variants in the human longevity gene FOXO3

Epithelial calcineurin controls microbiota-dependent intestinal tumor development

Publisher Correction: Identification and characterization of two functional variants in the human longevity gene FOXO3

Serum anti-NMDA receptor antibodies are linked to memory impairment 12 months after stroke

Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair

Species delimitation and mitonuclear discordance within a species complex of biting midges

NF-κB/RelA controlled A20 limits TRAIL-induced apoptosis in pancreatic cancer

Postoperative bioactive adrenomedullin is associated with the onset of ARDS and adverse outcomes in patients undergoing open thoracoabdominal aortic surgery

Expression of the NF-κB target gene IEX-1 (p22/PRG1) does not prevent cell death but instead triggers apoptosis in Hela cells

Inhibition of NF-κB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin

Correction: Inhibition of NF-κB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin

The antioxidant transcription factor Nrf2 modulates the stress response and phenotype of malignant as well as premalignant pancreatic ductal epithelial cells by inducing expression of the ATF3 splicing variant ΔZip2

Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes

Native mass spectrometry identifies the HybG chaperone as carrier of the Fe(CN)₂CO group during maturation of E. coli [NiFe]-hydrogenase 2

MTOR inhibitor-based combination therapies for pancreatic cancer

PKCμ prevents CD95-mediated apoptosis and enhances proliferation in pancreatic tumour cells

CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-κB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells

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