Enzyme I (EI)—a component of the bacterial phosphotransferase signal transduction system—undergoes large conformational rearrangements upon substrate binding. Here the authors show that the EI open-to-closed conformational switch occurs through suppression of micro- to millisecond dynamics of C-terminal domain.
- Vincenzo Venditti
- Vitali Tugarinov
- G. Marius Clore
