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Showing 1–4 of 4 results
Advanced filters: Author: Alexander Gruhl Clear advanced filters

  • Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.

    • Fabienne Läderach
    • Ioannis Piteros
    • Christian Münz
    Research
    Nature
    Volume: 646, P: 171-179

  • This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

    • Ian Dunham
    • Anshul Kundaje
    • Ewan Birney
    ResearchOpen Access
    Nature
    Volume: 489, P: 57-74

  • The mammalian transcription factors Oct4 and Pou2 are implicated in germ cell pluripotency induction and maintenance. Tapia and colleagues find that axolotl Pou2 and Oct4 reprogram mouse and human fibroblasts to a pluripotent state, suggesting ancestral Oct4 and Pou2 gene function is evolutionarily conserved.

    • Natalia Tapia
    • Peter Reinhardt
    • Hans R. Schöler
    Research
    Nature Communications
    Volume: 3, P: 1-12