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Showing 1–10 of 10 results
Advanced filters: Author: Alexander Johnson-Buck Clear advanced filters

  • MicroRNAs regulate gene expression through selective pairing with target mRNAs. Here, the authors reveal distinct, mutually exclusive binding modes of miRISC at the 5′ seed and 3′ non-seed regions, advancing understanding of RNA silencing mechanisms.

    • Tanmay Chatterjee
    • Shankar Mandal
    • Nils G. Walter
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-15

  • META-SiM brings foundation model power to single-molecule time traces, excelling across diverse analysis tasks. Paired with the web-based META-SiM Projector and entropy mapping, it rapidly reveals hidden molecular behaviors inaccessible by other means.

    • Jieming Li
    • Leyou Zhang
    • Nils G. Walter
    Research
    Nature Methods
    Volume: 22, P: 2149-2160

  • Traditional robots need to store internal representations of their goals and environment, and to coordinate sensing and the movement of components required in response. Individual molecules are limited in their ability to store complex information, but robotic behaviour can still be realized — as has now been shown with DNA walkers, which can carry out a sequence of actions such as 'start', 'follow', 'turn' and 'stop' that are programmed into the DNA landscape on which the walkers move.

    • Kyle Lund
    • Anthony J. Manzo
    • Hao Yan
    Research
    Nature
    Volume: 465, P: 206-210

  • Traces from single-molecule fluorescence microscopy (SMFM) experiments exhibit photophysical artifacts that typically make analysis time-consuming. Here, the authors have developed an easily accessible software, AutoSiM, for two distinct applications of deep learning to the efficient processing of SMFM time traces.

    • Jieming Li
    • Leyou Zhang
    • Nils G. Walter
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Cells compartmentalize enzymes for enhanced efficiency of their metabolic pathways. Here, the authors describe a self-assembly approach to construct DNA nanocaged enzymes for enhancing catalytic activity and stability, and observe an inversed correlation between the protein size and the activity enhancement.

    • Zhao Zhao
    • Jinglin Fu
    • Hao Yan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • DNA nanoswitch calipers can measure distances within single molecules with atomic resolution. Applied to single-molecule proteomics, they can enable the identification and quantification of molecules in trace samples via mechanical fingerprinting.

    • Prakash Shrestha
    • Darren Yang
    • Wesley P. Wong
    Research
    Nature Nanotechnology
    Volume: 16, P: 1362-1370