Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–9 of 9 results
Advanced filters: Author: Alexander Loewer Clear advanced filters

  • Genome-wide analysis and genetic manipulation at loci regulated by p53, E2F4 and RFX7 show that convergent promoters with similar epigenetic features can be co-regulated and simultaneously expressed in the same direction.

    • Elina Wiechens
    • Flavia Vigliotti
    • Martin Fischer
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 206-217

  • Increasing residual helicity in the p53 transcriptional activation domain strengthened interactions with Mdm2, resulting in alterations in p53 protein dynamics, impaired transcription of target genes and failure to promote cell cycle arrest.

    • Wade Borcherds
    • François-Xavier Theillet
    • Gary W Daughdrill
    Research
    Nature Chemical Biology
    Volume: 10, P: 1000-1002

  • Protein p53 plays key roles in cellular stress responses and is frequently deregulated in cancer. Here the authors show that infection with chlamydiae activates the ubiquitin ligase MDM2 in infected cells, leading to proteasomal degradation of p53 and thus promoting apoptosis resistance.

    • Erik González
    • Marion Rother
    • Thomas F. Meyer
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-10

  • The complex web of regulation that surrounds the tumour suppressor p53 is well known, but few have considered the effect that this has on the dynamics of p53 itself. This forward-looking Perspective speculates on the insights that we might gain by examining the p53 dynamics in individual tumour cells.

    • Eric Batchelor
    • Alexander Loewer
    • Galit Lahav
    Reviews
    Nature Reviews Cancer
    Volume: 9, P: 371-377

  • The authors used human embryonic stem cells or induced pluripotent stem cells to derive sensory neurons that have biochemical and electrophysiological properties similar to touch receptors, including the ability to transduce mechanical stimuli into electrical activity. Using CRISPR/Cas9 gene targeting technology, they also show that the mechanosensitivity of these cells relies entirely on the expression of PIEZO2.

    • Katrin Schrenk-Siemens
    • Hagen Wende
    • Jan Siemens
    Research
    Nature Neuroscience
    Volume: 18, P: 10-16