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Cxcl10⁺ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation

Mildner and colleagues characterize two subsets (Cxcl10⁺ and Saa3⁺) of monocytes with pathogenic potential in the central nervous system of mice with experimentally induced autoimmune encephalomyelitis and show these pathogenic cells are not derived from Ly6C⁺ monocytes, but from early myeloid cell progenitors.

Amir Giladi
Lisa Katharina Wagner
Alexander Mildner
Research20 Apr 2020
Nature Immunology

Volume: 21, P: 525-534
Author Correction: Cxcl10⁺ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation

Amir Giladi
Lisa Katharina Wagner
Alexander Mildner
Amendments and Corrections08 Jun 2020
Nature Immunology

Volume: 21, P: 962
Publisher Correction: Cxcl10⁺ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation

Amir Giladi
Lisa Katharina Wagner
Alexander Mildner
Amendments and Corrections24 Jun 2020
Nature Immunology

Volume: 21, P: 962
Identification of environmental factors that promote intestinal inflammation

The herbicide propyzamide increases inflammation in the small and large intestine, and the AHR–NF-κB–C/EBPβ signalling axis—which operates in T cells and dendritic cells to promote intestinal inflammation—is targeted by propyzamide.

Liliana M. Sanmarco
Chun-Cheih Chao
Francisco J. Quintana
Research20 Oct 2022
Nature

Volume: 611, P: 801-809
IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology

Macrophages and dendritic cells contribute to gut homeostasis and mucosal immune defense. Here, Aychek et al. describe an IL-23-based crosstalk between these cells that prevents lethal immunopathology during Citrobacter rodentiuminfection.

Tegest Aychek
Alexander Mildner
Steffen Jung
ResearchOpen Access12 Mar 2015
Nature Communications

Volume: 6, P: 1-10
Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow

Hematopoietic stem cells must be shielded from toxic and inflammatory insults to ensure lifelong blood cell production. Lapidot and colleagues identify a rare bone marrow macrophage population that protects hematopoietic stem cells.

Aya Ludin
Tomer Itkin
Tsvee Lapidot
Research16 Sept 2012
Nature Immunology

Volume: 13, P: 1072-1082
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes

Celia M Kassmann
Corinna Lappe-Siefke
Klaus-Armin Nave
Research22 Jul 2007
Nature Genetics

Volume: 39, P: 969-976
Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice

Geert van Loo
Rossana De Lorenzi
Manolis Pasparakis
Research06 Aug 2006
Nature Immunology

Volume: 7, P: 954-961
Grid-like entorhinal representation of an abstract value space during prospective decision making

Values of choice options often change over time. Here, the authors show that during prospective decision making the entorhinal cortex encodes changing values using a grid-like representation, suggesting the formation of a cognitive value map.

Alexander Nitsch
Mona M. Garvert
Christian F. Doeller
ResearchOpen Access09 Feb 2024
Nature Communications

Volume: 15, P: 1-20
Microglia in the adult brain arise from Ly-6C^hiCCR2⁺ monocytes only under defined host conditions

Alexander Mildner
Hauke Schmidt
Marco Prinz
Research18 Nov 2007
Nature Neuroscience

Volume: 10, P: 1544-1553
Clonal allelic predetermination of immunoglobulin-κ rearrangement

Immunoglobulin genes are expressed from either the maternal or paternal chromosome; it is now shown that in early haematopoietic stem cells, an individual cell can choose either of the two alleles, but as they develop they become committed to only one.

Marganit Farago
Chaggai Rosenbluh
Yehudit Bergman
Research30 Sept 2012
Nature

Volume: 490, P: 561-565
RNA viruses can hijack vertebrate microRNAs to suppress innate immunity

Here it is proposed that RNA viruses can adapt to use the antiviral properties of microRNAs to limit viral replication and suppress innate immunity in particular cell types, and this restriction can lead to exacerbation of disease severity.

Derek W. Trobaugh
Christina L. Gardner
William B. Klimstra
Research18 Dec 2013
Nature

Volume: 506, P: 245-248
Separating the wheat from the chaff – a strategy to utilize plant genetic resources from ex situ genebanks

Jens Keilwagen
Benjamin Kilian
Swetlana Friedel
ResearchOpen Access10 Jun 2014
Scientific Reports

Volume: 4, P: 1-6

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Cxcl10⁺ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation

Author Correction: Cxcl10⁺ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation

Publisher Correction: Cxcl10⁺ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation

Identification of environmental factors that promote intestinal inflammation

IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow

Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes

Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice

Grid-like entorhinal representation of an abstract value space during prospective decision making

Microglia in the adult brain arise from Ly-6C^hiCCR2⁺ monocytes only under defined host conditions

Clonal allelic predetermination of immunoglobulin-κ rearrangement

RNA viruses can hijack vertebrate microRNAs to suppress innate immunity

Separating the wheat from the chaff – a strategy to utilize plant genetic resources from ex situ genebanks

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