Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–6 of 6 results
Advanced filters: Author: Alexander Pryor Clear advanced filters

  • Dense calcium imaging combined with co-registered high-resolution electron microscopy reconstruction of the brain of the same mouse provide a functional connectomics map of tens of thousands of neurons of a region of the primary cortex and higher visual areas.

    • J. Alexander Bae
    • Mahaly Baptiste
    • Chi Zhang
    ResearchOpen Access
    Nature
    Volume: 640, P: 435-447

  • Polymerase μ (Polμ) participates in the repair of DNA double-strand breaks (DSBs) via the nonhomologous end-joining (NHEJ) pathway. Here, the authors determine the crystal structure of a pre-catalytic ternary complex of human Polμ with a bound DSB substrate and they obtain further mechanistic insights by allowing the insertion reaction to proceed in crystallo, which enabled them to determine a Polμ structure with incomplete incorporation and the structure of the post-catalytic nicked state.

    • Andrea M. Kaminski
    • John M. Pryor
    • Katarzyna Bebenek
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Th17 cells are critical players in the immunopathology of a range of autoimmune diseases. Here the authors implicate Hedgehog signaling in Th17 polarization and in the immunopathology of intestinal inflammation in murine models and suggest therapeutic targeting of Hedgehog signaling in the context of inflammatory bowel disease.

    • Joachim Hanna
    • Flavio Beke
    • Maike de la Roche
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18