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Showing 1–3 of 3 results

Advanced filters: Author: Alexander Strudwick Young Clear advanced filters

Family-based genome-wide association study designs for increased power and robustness

This study develops family-based genome-wide association study methods that maximize power in homogeneous samples through inclusion of singletons and in diverse samples by using all available parental genotypes.

Junming Guan
Tammy Tan
Alexander Strudwick Young
ResearchOpen Access10 Mar 2025
Nature Genetics

Volume: 57, P: 1044-1052
Examining the role of common variants in rare neurodevelopmental conditions

Patients with neurodevelopmental conditions without a monogenic diagnosis have a higher polygenic burden than those with a monogenic diagnosis. Non-transmitted common alleles in the parents are associated with the child’s phenotype, and the common and rare variants conferring risk are correlated.

Qin Qin Huang
Emilie M. Wigdor
Hilary C. Martin
ResearchOpen Access20 Nov 2024
Nature

Volume: 636, P: 404-411
The importance of family-based sampling for biobanks

This Perspective discusses the strengths and limitations of future biobank sampling strategies based on oversampling close relatives as opposed to the current population-based approach.

Neil M. Davies
Gibran Hemani
Matthew C. Keller
Reviews23 Oct 2024
Nature

Volume: 634, P: 795-803