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Showing 1–3 of 3 results
Advanced filters: Author: Alexander V. Chertovich Clear advanced filters

  • Genomes are partitioned into topologically associating domains (TADs). Here the authors present single-nucleus Hi-C maps in Drosophila at 10 kb resolution, demonstrating the presence of chromatin compartments in individual nuclei, and partitioning of the genome into non-hierarchical TADs at the scale of 100 kb, which resembles population TAD profiles.

    • Sergey V. Ulianov
    • Vlada V. Zakharova
    • Sergey V. Razin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • The role of the nuclear lamina (NL) in chromatin architecture is still poorly understood. Here, the authors provide evidence that disruption of the NL in Drosophila cells leads to overall chromatin compaction and repositioning from the nuclear envelope, whereas lamina-associated regions become less compacted and transcription within them is increased.

    • Sergey V. Ulianov
    • Semen A. Doronin
    • Yuri Y. Shevelyov
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11