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Functional dissection of complex trait variants at single-nucleotide resolution

Massively parallel reporter assays across five cell types identify thousands of causal, noncoding regulatory variants among 220,000 loci, revealing diverse regulatory mechanisms shaping complex traits and disease.

Layla Siraj
Rodrigo I. Castro
Ryan Tewhey
ResearchOpen Access25 Feb 2026
Nature

P: 1-11

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Functional dissection of complex trait variants at single-nucleotide resolution

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