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Showing 1–3 of 3 results
Advanced filters: Author: Alexandr P. Kornev Clear advanced filters

  • Allostery, communication between distant parts of a protein, is a key element of enzyme catalysis. Here the authors combine existing experimental data with molecular dynamics simulations and Markov state models to provide insight into the mechanism of ligand-induced allostery within the cyclicnucleotide-binding domain of protein kinase A.

    • Robert D. Malmstrom
    • Alexandr P. Kornev
    • Rommie E. Amaro
    Research
    Nature Communications
    Volume: 6, P: 1-11

  • Structural analysis of protein kinase A had previously focused on static pictures with bound inhibitors. The first analyses of the protein with a substrate peptide identify dynamic hot spots and slow steps in catalysis, pointing toward a model of conformational selection in binding.

    • Larry R Masterson
    • Cecilia Cheng
    • Gianluigi Veglia
    Research
    Nature Chemical Biology
    Volume: 6, P: 821-828

  • The activity of protein kinases is regulated by domains that are associated with the kinase core, by interacting proteins and by their incorporation into large macromolecular complexes. Thus, understanding kinase signalling requires the structural characterization of entire complexes, as exemplified by studies of cyclic AMP-dependent protein kinase (PKA).

    • Susan S. Taylor
    • Ronit Ilouz
    • Alexandr P. Kornev
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 646-658