Genetic ablation of β-catenin in the embryonic ventral forebrain restricted proliferation of neural precursors in the medial ganglionic eminence, resulting in fewer cholinergic projection neurons in basal forebrain and fewer calbindin- and somatostatin-positive interneurons in the cortex. This work suggests a crucial role for canonical Wnt signaling in ventral forebrain neurogenesis.
- Alexandra A Gulacsi
- Stewart A Anderson
