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Showing 1–4 of 4 results
Advanced filters: Author: Alexandra Bortnick Clear advanced filters

  • Precursor cells entering the thymus have non-T cell potential, yet T cell development is clearly favored. A mechanism dedicated to repressing conflicting myeloid cell fate early during the establishment of T cell identity has now been found.

    • Alexandra Bortnick
    • Cornelis Murre
    News & Views
    Nature Immunology
    Volume: 14, P: 1209-1210

  • In neutrophil progenitor cells, stopping the process of loop extrusion by depleting nipped-B-like protein (NIPBL) results in the assembly of polymorphonuclear structures and the activation of a neutrophil-specific gene program.

    • Indumathi Patta
    • Maryam Zand
    • Cornelis Murre
    Research
    Nature
    Volume: 627, P: 196-203

  • Antibody production in plasma cells involves the unfold protein response (UPR), but how this is regulated is not clear. Here the authors show that mTORC1 signalling but not Xbp1-mediated transcription regulation in activated B cells is important for the induction of a UPR-related transcriptome that precedes full plasma cell functions.

    • Brian T. Gaudette
    • Derek D. Jones
    • David Allman
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • The transcription factor Aire restrains the transcriptional duration and amplitude of tissue-specific self-antigens by opposing the activity of the chromatin remodeler Brg1—a process required for immune tolerance.

    • Alexandra Bortnick
    • Cornelis Murre
    News & Views
    Nature Immunology
    Volume: 19, P: 100-101