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Caudate serotonin signaling during social exchange distinguishes essential tremor and Parkinson’s disease patients

Measurements of dopamine, serotonin and norepinephrine in the caudate of conscious humans reveal a neurochemical boundary between patients with essential tremor and Parkinson’s disease based on serotonin release evoked by monetary offers.

Alec E. Hartle
Kenneth T. Kishida
W. Matt Howe
ResearchOpen Access02 Sept 2025
Nature Communications

Volume: 16, P: 1-10
Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions

New instrumental learning occurs through an unexpected delivery of a rewarding stimulus or the withdrawal of a punishing stimulus. The authors show that D1 receptor-expressing medium spiny neurons (MSNs) in the anterior dorsolateral striatum encode newly learned instrumental actions whereas D2 MSNs promote the expression of habitual actions.

Alexander C. W. Smith
Sietse Jonkman
Paul J. Kenny
ResearchOpen Access25 Aug 2021
Nature Communications

Volume: 12, P: 1-16
Obesity impairs brain responses to nutrients

Post-ingestive signals of nutrient availability can drive food reward and neural responses independently of orosensory signals. van Galen et al. demonstrate that brain responses to these post-ingestive signals are impaired in people with obesity

Mary Elizabeth Baugh
Alexandra G. DiFeliceantonio
News & Views12 Jun 2023
Nature Metabolism

Volume: 5, P: 920-921
Unique contributions of parvalbumin and cholinergic interneurons in organizing striatal networks during movement

Causal manipulations combined with simultaneous recordings of both interneurons and medium spiny neurons in the striatum reveal dissociable contributions of cholinergic and parvalbumin interneurons in movement initiation and termination.

Howard J. Gritton
William M. Howe
Xue Han
Research25 Feb 2019
Nature Neuroscience

Volume: 22, P: 586-597
Dopamine and diet-induced obesity

In 2010, Johnson and Kenny provided conclusive evidence that extended access to a Western-style diet promotes addictive-like behavior in rats by downregulating D₂ receptors while promoting obesity. This focused attention on the parallels between drug addiction and overeating and fueled a decade of food addiction research.

Alexandra G. DiFeliceantonio
Dana M. Small
News & Views17 Dec 2018
Nature Neuroscience

Volume: 22, P: 1-2
Semaglutide and Tirzepatide reduce alcohol consumption in individuals with obesity

Fatima Quddos
Zachary Hubshman
Warren K. Bickel
ResearchOpen Access28 Nov 2023
Scientific Reports

Volume: 13, P: 1-12
No evidence for an association between obesity and milkshake liking

Kathryn M. Wall
Michael C. Farruggia
Dana M. Small
Research12 May 2020
International Journal of Obesity

Volume: 44, P: 1668-1677

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Caudate serotonin signaling during social exchange distinguishes essential tremor and Parkinson’s disease patients

Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions

Obesity impairs brain responses to nutrients

Unique contributions of parvalbumin and cholinergic interneurons in organizing striatal networks during movement

Dopamine and diet-induced obesity

Semaglutide and Tirzepatide reduce alcohol consumption in individuals with obesity

No evidence for an association between obesity and milkshake liking

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