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Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

Rafael E. Carazo-Salas
Giulia Guarguaglini
Iain W. Mattaj
Research08 Jul 1999
Nature

Volume: 400, P: 178-181
Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling

Sensation of environmental changes is vital for organismal homeostasis. Here, the authors report that protein degradation in the gut of Caenorhabditis elegans is regulated through insulin and calcineurin signalling upon neuronal sensation of temperature changes.

Alexandra Segref
Kavya L. Vakkayil
Thorsten Hoppe
ResearchOpen Access05 Oct 2022
Nature Communications

Volume: 13, P: 1-17
The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis

The deubiquitylating enzyme ataxin 3 causes polyglutamine disease. In Caenorhabditis elegans, an ataxin-3 orthologue cooperates with the ubiquitin-selective chaperone CDC-48/p97 to control lifespan in a manner that may involve ubiquitin chain editing.

Kirsten Kuhlbrodt
Philipp Christoph Janiesch
Thorsten Hoppe
Research13 Feb 2011
Nature Cell Biology

Volume: 13, P: 273-281
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

Nematodes define a new role for sirtuins in lifespan extension, in which the sirtuin product nicotinamide is converted to a substrate for aldehyde oxidase; turnover of this enzyme generates hydrogen peroxide, causing upregulation of defense mechanisms that promote longevity.

Kathrin Schmeisser
Johannes Mansfeld
Michael Ristow
Research29 Sept 2013
Nature Chemical Biology

Volume: 9, P: 693-700
DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

In Caenorhabditis elegans, genome instability in the form of exogenous and endogenous DNA damage in germ cells evokes elevated heat- and oxidative-stress resistance in somatic tissues; this is mediated by MPK-1, which triggers the induction of putative secreted peptides associated with innate immunity, leading to activation of the ubiquitin–proteasome system.

Maria A. Ermolaeva
Alexandra Segref
Björn Schumacher
Research25 Aug 2013
Nature

Volume: 501, P: 416-420

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Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling

The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

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