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Showing 1–9 of 9 results
Advanced filters: Author: Alexandra Tsitsiklis Clear advanced filters

  • Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

    • Harry Pickering
    • Joanna Schaenman
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • In this work, authors assess airway microbiome dynamics to show bacterial pneumonia in critically ill COVID-19 patients is significantly associated with death, corticosteroid treatment, disruption of the lung microbiome and a distinct pulmonary host response.

    • Natasha Spottiswoode
    • Alexandra Tsitsiklis
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • The difference between children and adults in response to SARS-CoV-2 infection is not clearly established. Here the authors use gene expression analysis of nasopharyngeal samples from children and adults and show a higher level of immune response in children compared to adults, including of B and T cell activation.

    • Eran Mick
    • Alexandra Tsitsiklis
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • The role of IgG glycosylation in the immune response has been studied, but less is known about IgM glycosylation. Here the authors characterize glycosylation of SARS-CoV-2 spike specific IgM and show that it correlates with COVID-19 severity and affects complement deposition.

    • Benjamin S. Haslund-Gourley
    • Kyra Woloszczuk
    • Mary Ann Comunale
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Post-acute sequelae of SARS-CoV-2 (PASC) is still not well understood. Here the authors provide patient reported outcomes from 590 hospitalized COVID-19 patients and show association of PASC with higher respiratory SARS-CoV-2 load and circulating antibody titers, and in some an elevation in circulating fibroblast growth factor 21.

    • Al Ozonoff
    • Naresh Doni Jayavelu
    • Nadine Rouphael
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Here, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to be potentially modulated by dexamethasone.

    • Aartik Sarma
    • Stephanie A. Christenson
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Dexamethasone has been used in the treatment of critically ill COVID-19 patients. Here the authors apply transcriptomics to investigate the effects of dexamethasone treatment in COVID-19 patients, and show both systemic and compartment-specific effects.

    • Lucile P. A. Neyton
    • Ravi K. Patel
    • Gabriela K. Fragiadakis
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14