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Showing 1–6 of 6 results

Advanced filters: Author: Alexandra Wuest Clear advanced filters

SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence

Using mouse pancreatic cancer models, Tsanov et al. show that reactivation of SMAD4 at metastatic sites promotes tumor growth in the lung through RUNX1 but restrains metastatic growth through KLF4 in the liver, influenced by organ-specific epigenetic states.

Kaloyan M. Tsanov
Francisco M. Barriga
Scott W. Lowe
ResearchOpen Access25 Sept 2025
Nature Cancer

P: 1-18
Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease

Leibold and colleagues develop a method to somatically introduce oncogenic lesions into the stomach epithelium, which recapitulates the histological, molecular and clinical features of human gastric cancer.

Josef Leibold
Kaloyan M. Tsanov
Scott W. Lowe
ResearchOpen Access04 Jan 2024
Nature Cancer

Volume: 5, P: 315-329
High-throughput evaluation of genetic variants with prime editing sensor libraries

Prime editing sensor libraries evaluate diverse genetic variants in their endogenous genomic contexts.

Samuel I. Gould
Alexandra N. Wuest
Francisco J. Sánchez Rivera
ResearchOpen Access12 Mar 2024
Nature Biotechnology

P: 1-15
Generation of precision preclinical cancer models using regulated in vivo base editing

The function of single-nucleotide variants can now be tested in a base editor mouse model.

Alyna Katti
Adrián Vega-Pérez
Lukas E. Dow
Research10 Aug 2023
Nature Biotechnology

Volume: 42, P: 437-447
MACHETE identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune evasion and metastasis

Barriga et al. develop MACHETE, a genome engineering strategy enabling the flexible modeling of megabase-sized deletions and show that the concomitant loss of the interferon cluster with CDKN2A/B deletions on 9p21.3 enhances immune evasion.

Francisco M. Barriga
Kaloyan M. Tsanov
Scott W. Lowe
ResearchOpen Access07 Nov 2022
Nature Cancer

Volume: 3, P: 1367-1385
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants

Improved base editing libraries enable high-throughput functional analysis of single-nucleotide variants in cancer.

Francisco J. Sánchez-Rivera
Bianca J. Diaz
Lukas E. Dow
Research14 Feb 2022
Nature Biotechnology

Volume: 40, P: 862-873