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Showing 1–4 of 4 results
Advanced filters: Author: Alexandre Karras Clear advanced filters

  • Pathology-oriented multiplexing (PathoPlex) represents a framework for widespread access to multiplexed imaging and computational image analysis of clinical specimens at a relatively high throughput and subcellular resolution.

    • Malte Kuehl
    • Yusuke Okabayashi
    • Victor G. Puelles
    ResearchOpen Access
    Nature
    Volume: 644, P: 516-526

  • Hemophagocytic syndrome (HPS), which was first described in 1939, is a heterogeneous disorder characterized by excessive activation and proliferation of non-malignant macrophages. HPS can cause acute kidney injury and nephrotic syndrome; in addition, renal transplant recipients are at risk of developing HPS as a result of their immunocompromised state. This Review summarizes the presentation, causes, pathophysiology and renal features of HPS for the benefit of the practicing nephrologist.

    • Alexandre Karras
    Reviews
    Nature Reviews Nephrology
    Volume: 5, P: 329-336

  • In both focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN), kidney injury is characterised by the invasion of glomerular tufts by parietal epithelial cells (PECs). Here Lazareth et al. identify the tetraspanin CD9 as a key regulator of PEC migration, and find its upregulation in FSGS and CGN contributes to kidney injury in both diseases.

    • Hélène Lazareth
    • Carole Henique
    • Pierre-Louis Tharaux
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Crescentic rapidly progressive glomerulonephritis is a severe form of glomerula disease characterized by podocyte proliferation and migration. Here Henique et al. demonstrate that inhibition of miRNA-92a prevents kidney failure by promoting the expression of CDK inhibitor p57Kip2 that regulates podocyte cell cycle.

    • Carole Henique
    • Guillaume Bollée
    • Pierre-Louis Tharaux
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15