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Showing 1–6 of 6 results

Advanced filters: Author: Alexey Efremov Clear advanced filters

The locking mechanism of human TRPV6 inhibition by intracellular magnesium

TRP channel TRPV6 is a regulator of Ca2+ homeostasis. Here, authors decipher the mechanism of TRPV6 inhibition by intracellular Mg2+ ions that bind to four sites around the intracellular pore entrance and lock the channel in the closed state.

Arthur Neuberger
Alexey Shalygin
Alexander I. Sobolevsky
ResearchOpen Access06 Nov 2025
Nature Communications

Volume: 16, P: 1-16
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins

High-resolution (≤1.2 Å) structures of functional states of bacteriorhodopsin reveal the molecular mechanism for generating a membrane proton electrochemical gradient, a key event of cell bioenergetics driving ATP synthesis.

Valentin Borshchevskiy
Kirill Kovalev
Valentin Gordeliy
Research28 Apr 2022
Nature Structural & Molecular Biology

Volume: 29, P: 440-450
Structure-based rational design of an enhanced fluorogen-activating protein for fluorogens based on GFP chromophore

Structural analyses guide the rational design of mutant fluorogen-activating proteins with enhanced fluorescence.

Marina V. Goncharuk
Nadezhda S. Baleeva
Mikhail S. Baranov
ResearchOpen Access15 Jul 2022
Communications Biology

Volume: 5, P: 1-10
Clinical and analytical validation of a combined RNA and DNA exome assay across a large tumor cohort

Yudina et al. present clinical validation guidelines for an integrated RNA and DNA sequencing assay. Applied to over 2000 tumors, the assay enhances precision oncology by capturing complex variants missed by DNA-only testing.

Anastasiya Yudina
Cagdas Tazearslan
Alexander Bagaev
ResearchOpen Access16 Jun 2025
Communications Medicine

Volume: 5, P: 1-21
Kalium 2.0, a comprehensive database of polypeptide ligands of potassium channels

Valentin M. Tabakmakher
Nikolay A. Krylov
Alexander A. Vassilevski
ResearchOpen Access27 May 2019
Scientific Data

Volume: 6, P: 1-8