In the Hippo pathway, the atypical cadherins Fat and Dachsous modulate tissue growth. Harvey and colleagues have identified two regulators of the Hippo pathway, the WD40 protein Riquiqui and the DYRK kinase Minibrain, that act downstream of Dachsous to inhibit Wts and promote Yki-dependent tissue growth.
- Joffrey L. Degoutin
- Claire C. Milton
- Kieran F. Harvey