Regulatory T cells (Treg) develop in the thymus via two pathways including CD25−Foxp3lo and CD25+Foxp3− cells. Here, the authors show that lymphotoxin acts as an inhibitory checkpoint of thymic Treg development, fine-tuning the Foxp3lo precursor pathway by limiting IL-4 production in medullary thymic epithelial cells.
- Alexia Borelli
- Jérémy C. Santamaria
- Magali Irla
