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Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure

Post-translational modification of microtubules by detyrosination is prevalent in failing human cardiomyocytes and inhibits cardiomyocyte contraction, suggesting a new therapeutic strategy for improving heart function.

Christina Yingxian Chen
Matthew A. Caporizzo
Benjamin L. Prosser
Research11 Jun 2018
Nature Medicine

Volume: 24, P: 1225-1233

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Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure

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