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Showing 1–9 of 9 results
Advanced filters: Author: Alfred A. Antson Clear advanced filters

  • The crystal structure of the trp RNA-binding attenuation protein of Bacillus subtilis solved at 1.8 Å resolution reveals a novel structural arrangement in which the eleven subunits are stabilized through eleven intersubunit β-sheets to form a β-wheel with a large central hole. The nature of the binding of L-tryptophan in clefts between adjacent β-sheets in the β-wheel suggests that this binding induces conformational changes in the flexible residues 25-33 and 49-52. It is argued that upon binding, the messenger RNA target forms a matching circle in which eleven U/GAG repeats are bound to the surface of the protein ondecamer modified by the binding of L-tryptophan.

    • Alfred A. Antson
    • John Otridge
    • Paul Gollnick
    Research
    Nature
    Volume: 374, P: 693-700

  • A cryo-electron microscopy reconstruction of the virus ΦcrAss001 provides insights into the functions of the viral gene products in capsid assembly and infection.

    • Oliver W. Bayfield
    • Andrey N. Shkoporov
    • Alfred A. Antson
    ResearchOpen Access
    Nature
    Volume: 617, P: 409-416

  • Solid state nanopores are robust but the sizing can be variable, whereas protein nanopores are precisely sized but lack robustness. Here the authors cork a solid state nanopore with the DNA-translocating portal protein from the virus G20c to obtain a lipid-free hybrid nanopore that can sense various biopolymers.

    • Benjamin Cressiot
    • Sandra J. Greive
    • Meni Wanunu
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-7

  • Questions have arisen as to whether patients with severe COVID-19 disease can generate a T cell response against SARS-CoV-2. Tao Dong and colleagues report that convalescent patients with COVID-19 harbor functional memory CD4+ and CD8+ T cells that recognize multiple epitopes that span the viral proteome. CD4+ T cells predominated the memory response in patients with severe disease, whereas higher proportions of CD8+ T cells were found in patients with mild disease.

    • Yanchun Peng
    • Alexander J. Mentzer
    • Tao Dong
    Research
    Nature Immunology
    Volume: 21, P: 1336-1345

  • Repeating RNA sequences often serve as protein targets during regulatory processes involving single-stranded RNA (ssRNA). New data on the HutP protein show how it is activated and binds a repeat-containing ssRNA. Together with previous work, these studies demonstrate the versatility of RNA-binding proteins in regulating transcription in bacteria.

    • Paul Gollnick
    • Alfred Antson
    News & Views
    Nature Structural & Molecular Biology
    Volume: 12, P: 289-290