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Showing 1–3 of 3 results

Advanced filters: Author: Alfredo Gonzalez-Sulser Clear advanced filters

Reversal of cell, circuit and seizure phenotypes in a mouse model of DNM1 epileptic encephalopathy

One third of all epilepsies are treatment-resistant. Here, the authors show in a genetic model of epilepsy that a repurposed drug can correct cell defects, brain circuits and seizure-like events by accelerating endocytosis.

Katherine Bonnycastle
Katharine L. Dobson
Michael A. Cousin
ResearchOpen Access30 Aug 2023
Nature Communications

Volume: 14, P: 1-19
Grid cells' need for speed

Grid-firing fields of neurons in the entorhinal cortex are thought to require inputs encoding running speed. Glutamatergic projections from the medial septum may be one of the inputs that provide these speed signals.

Alfredo Gonzalez-Sulser
Matthew F Nolan
News & Views27 Dec 2016
Nature Neuroscience

Volume: 20, P: 1-2
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus

Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia can proceed normally even in the absence of these cells.

Mary O’Keeffe
Sam A. Booker
Giles E. Hardingham
ResearchOpen Access06 Jan 2025
Nature Neuroscience

Volume: 28, P: 268-279