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Showing 1–4 of 4 results
Advanced filters: Author: Aline Mariage Clear advanced filters

  • New enzymes for the efficient and stereoselective synthesis of chiral amines are of high interest for the pharmaceutical industry. Now, Grogan, Vergne-Vaxelaire and co-workers report the discovery, characterization, crystal structure and engineering of a family of native amine dehydrogenases for the preparation of chiral amines from ketones.

    • Ombeline Mayol
    • Karine Bastard
    • Carine Vergne-Vaxelaire
    Research
    Nature Catalysis
    Volume: 2, P: 324-333

  • Enzyme annotations often suffer from incomplete functional information for homologous sequences. Extrapolation from one characterized enzyme to multiple possible substrate-enzyme pairs, using bioinformatics and experimental approaches, leads to four distinct β-keto acid cleavage enzyme functional motifs and assignment of 14 new activities.

    • Karine Bastard
    • Adam Alexander Thil Smith
    • Marcel Salanoubat
    Research
    Nature Chemical Biology
    Volume: 10, P: 42-49

  • MetA and MetX are phylogenetically unrelated families of acyl-L-homoserine transferases. Experimental assignation of function and structural modeling of these families correct widespread misannotation, reveal convergence of function and uncover new functions in a subclass of MetX.

    • Karine Bastard
    • Alain Perret
    • Véronique de Berardinis
    Research
    Nature Chemical Biology
    Volume: 13, P: 858-866