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Showing 1–7 of 7 results
Advanced filters: Author: Alisa A. Garaeva Clear advanced filters

  • Mycobacteria produce small molecules (mycobactins) to acquire the essential nutrient iron. Here, Earp et al determine the cryo-EM structures of the mycobactin exporter MmpL4, which also effluxes the TB drug bedaquiline.

    • Jennifer C. Earp
    • Alisa A. Garaeva
    • Markus A. Seeger
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • ASCT2 is a Na+-dependent obligatory amino acid exchanger. Here, the authors untangle the structural basis of the exchange mechanism in ASCT2, revealing that structural rigidity and a high-affinity Na+ binding site effectively confine ASCT2 to an exchange mode.

    • Anna M. Borowska
    • Maria Gabriella Chiariello
    • Dirk J. Slotboom
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • How the human Alanine Serine Cysteine Transporter 2 (ASCT2) binds its substrates, neutral amino acids, and releases them on the cytoplasmic side remains unclear. Here authors present an inward-open structure of the human ASCT2 which shows that a hairpin serves as a gate in the inward-facing state.

    • Alisa A. Garaeva
    • Albert Guskov
    • Cristina Paulino
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-8

  • A cryo-EM structure of the human SLC1 transporter ASCT2 in the inward-facing conformation reveals the retrovirus-docking site and helps to elucidate the transport cycle. The transport domain is more solvent exposed than in most of the homolog structures.

    • Alisa A. Garaeva
    • Gert T. Oostergetel
    • Dirk J. Slotboom
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 515-521

  • Trinco et al. measure aspartate uptake rates in proteoliposomes containing purified prokaryotic Na+-coupled aspartate transporter GltTk. To overcome limitation of protein orientation, they use synthetic nanobody that blocks transporters from outside and reveal mechanistic features of Na+-aspartate symport that cannot be observed in detergent solution.

    • Gianluca Trinco
    • Valentina Arkhipova
    • Dirk J. Slotboom
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11