Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Alison Ciling Clear advanced filters

  • Omicron BA.1 is attenuated in infection models though the precise nature of this attenuation remains unknown as generating replication-competent viral genomes is challenging. Here the authors present pGLUE, a plasmid-based viral genome assembly and rescue strategy, to systematically characterize Omicron mutations and show that Omicron NSP6 has weakened lipid flow to replication organelles and reduced viral RNA replication.

    • Taha Y. Taha
    • Irene P. Chen
    • Melanie Ott
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Infection with Omicron after vaccination produces cross-neutralizing antibodies to other variants of concern, whereas this induces a limited response to non-Omicron variants in unvaccinated individuals.

    • Rahul K. Suryawanshi
    • Irene P. Chen
    • Melanie Ott
    ResearchOpen Access
    Nature
    Volume: 607, P: 351-355

  • A COVID-19 test implemented in an automated microfluidic device and leveraging isothermal RNA amplification followed by T7 transcription and Cas13-mediated cleavage of a quenched fluorophore rapidly detects SARS-CoV-2 RNA in saliva samples.

    • Sita S. Chandrasekaran
    • Shreeya Agrawal
    • Patrick D. Hsu
    Research
    Nature Biomedical Engineering
    Volume: 6, P: 944-956

  • Deploying two unrelated CRISPR nucleases in tandem, with multiplexed CRISPR RNAs and a chemically stabilized activator, creates a simple, one-step assay that can rapidly detect attomolar concentrations of RNA without needing target amplification.

    • Tina Y. Liu
    • Gavin J. Knott
    • Jennifer A. Doudna
    Research
    Nature Chemical Biology
    Volume: 17, P: 982-988