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Showing 1–18 of 18 results
Advanced filters: Author: Alison Conquest Clear advanced filters

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • Ancient DNA analysis of archaeological cat remains shows cats dispersed along trade routes from the Neolithic era onwards, while its gene pool shows admixture from multiple geographical sources and that the tabby allele originated in the Middle Ages.

    • Claudio Ottoni
    • Wim Van Neer
    • Eva-Maria Geigl
    Research
    Nature Ecology & Evolution
    Volume: 1, P: 1-7

  • Western science owes much to Islam's golden age — a debt that is often forgotten. To help redress the balance, Fuat Sezgin has reconstructed a host of scientific treasures using ancient Arabic texts. Alison Abbott reports.

    • Alison Abbott
    News
    Nature
    Volume: 432, P: 794-795

  • A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

    • Erola Pairo-Castineira
    • Sara Clohisey
    • J. Kenneth Baillie
    Research
    Nature
    Volume: 591, P: 92-98

  • BERLIN

    Nazi-era documents from the files of Adolf Butenandt, director of the Kaiser Wilhelm Institute for Biochemistry and later head of the Max Planck Society, will be opened for the first time this week.

    • Alison Abbott
    News
    Nature
    Volume: 403, P: 474-475

  • Explore the gory glories of forensic science, grapple with Tom Stoppard's take on consciousness, learn what it takes to live on Mars, re-enter Jurassic Park, dive into a coral reef and dally with Robert Oppenheimer. Daniel Cressey reports.

    • Daniel Cressey
    Books & Arts
    Nature
    Volume: 517, P: 18-20

  • Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

    • Heather J. Cordell
    • Younghun Han
    • Katherine A. Siminovitch
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • Megadroughts can be defined as persistent, multi-year droughts that are exceptional compared with other regional events during the Common Era. This Review discusses palaeo reconstructions of megadroughts over the past 2,000 years, and outlines the impact of anthropogenic forcing on the severity and frequency of observed and projected events.

    • Benjamin I. Cook
    • Jason E. Smerdon
    • Erika K. Wise
    Reviews
    Nature Reviews Earth & Environment
    Volume: 3, P: 741-757

  • This Review highlights how information from archaeology, history, palaeoecology and other past sources can, and should, be used to inform plans to enhance the sustainability and resilience of our societies.

    • Nicole Boivin
    • Alison Crowther
    Reviews
    Nature Ecology & Evolution
    Volume: 5, P: 273-284

  • Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

    • Malcolm G Dunlop
    • Sara E Dobbins
    • Richard S Houlston
    Research
    Nature Genetics
    Volume: 44, P: 770-776