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Showing 1–5 of 5 results
Advanced filters: Author: Alissa Trzeciak Clear advanced filters

  • Tissue-resident macrophages (TRM) are important mediators of local immunity. Here the authors show that the deficiency or inhibition of a kinase, WNK1, unlinks macrophage colony-stimulating factor signaling and resulted macropinocytosis with the downstream, potentially IRF8-mediated genetic program to bias progenitor differentiation to neutrophil instead of TRM.

    • Alissa J. Trzeciak
    • Zong-Lin Liu
    • Justin S. A. Perry
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • The degree of Treg self-antigen reactivity varies across experimental systems. Here the authors develop a new model of skin autoimmunity and show that the size of tissue-specific Treg pool in the thymus depends on AIRE, the availability of the tissue antigen, and its presentation by dendritic cells.

    • Jiqiang Lin
    • Lu Yang
    • Juan J. Lafaille
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Saavedra et al. show that broad-spectrum antibiotics impair homeostatic efferocytosis of macrophages in mice by affecting the gut microbiota. Microbial butyrate is shown to rescue homeostatic efferocytosis efficiency in vivo.

    • Pedro H. V. Saavedra
    • Alissa J. Trzeciak
    • Justin S. A. Perry
    Research
    Nature Metabolism
    Volume: 6, P: 1682-1694