Nature Search

Peptidoglycan–outer membrane attachment generates periplasmic pressure to prevent lysis in Gram-negative bacteria

Outer membrane attachment to peptidoglycan enables periplasmic pressure to build up and counter cytoplasmic turgor pressure, preventing lysis during osmotic challenges in Escherichia coli.

Michaël Deghelt
Seung-Hyun Cho
Jean-François Collet
Research29 Jul 2025
Nature Microbiology

Volume: 10, P: 1963-1974
Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families

Melanie M. Mahtani
Elisabeth Widén
Leif C. Groop
Research01 Sept 1996
Nature Genetics

Volume: 14, P: 90-94
Morphological map of under- and overexpression of genes in human cells

This Resource presents the genetic subset of the 136,000 chemical and genetic perturbations tested by the Joint Undertaking for Morphological Profiling (JUMP) Cell Painting Consortium and associated analysis of phenotypic profiles.

Srinivas Niranj Chandrasekaran
Eric Alix
Anne E. Carpenter
Research07 Aug 2025
Nature Methods

Volume: 22, P: 1742-1752
Impaired T cell and neoantigen retention in time-serial analysis of metastatic non-small cell lung cancer in patients unresponsive to TIL cell therapy

Wang et al. present T cell receptor sequencing of serial tumor and blood samples from TIL-treated patients with non-small cell lung cancer, identifying tumor-reactive clonotypes expressing dysfunctional programs in patients lacking clinical benefit.

Chao Wang
Xiaoqing Yu
Benjamin C. Creelan
Research08 May 2025
Nature Cancer

Volume: 6, P: 801-819
Author Correction: Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules

Dmitry L. Usanov
Alix I. Chan
David R. Liu
Amendments and Corrections01 Oct 2019
Nature Chemistry

Volume: 11, P: 1067
Discovery and molecular basis of subtype-selective cyclophilin inhibitors

DNA-templated compound library screening and structure-guided hit optimization resulted in the identification of selective macrocyclic inhibitors of cyclophilin isoforms CypD and CypE.

Alexander A. Peterson
Aziz M. Rangwala
David R. Liu
ResearchOpen Access26 Sept 2022
Nature Chemical Biology

Volume: 18, P: 1184-1195
Long-term cellular immunity of vaccines for Zaire Ebola Virus Diseases

In this immunological ancillary study of the PREVAC trial, the authors show that approved Ebola virus vaccines induce memory T-cell responses that persist during the five year follow-up after initial vaccination.

Aurélie Wiedemann
Edouard Lhomme
Huanying Zhou
ResearchOpen Access03 Sept 2024
Nature Communications

Volume: 15, P: 1-15
The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

AMPK and Parkin keep the necrosome in check. Lee et al. show that AMPK activates Parkin and prevents RIPK1−RIPK3 complex formation by promoting RIPK3 ubiquitination, thereby negatively regulating necroptosis, inflammation and tumour initiation.

Seung Baek Lee
Jung Jin Kim
Zhenkun Lou
Research29 Jul 2019
Nature Cell Biology

Volume: 21, P: 940-951
Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules

A second-generation DNA-templated library of 256,000 small-molecule macrocycles has been developed. The improved method was created by streamlining and integrating multiple aspects of DNA-encoded and DNA-templated library synthesis methodology. In vitro selection of the macrocycle library against insulin-degrading enzyme enabled the discovery of potent inhibitors.

Dmitry L. Usanov
Alix I. Chan
David R. Liu
Research02 Apr 2018
Nature Chemistry

Volume: 10, P: 704-714
Effects of transcranial direct current stimulation combined with listening to preferred music on memory in older adults

Ricky Chow
Alix Noly-Gandon
Claude Alain
ResearchOpen Access16 Jun 2021
Scientific Reports

Volume: 11, P: 1-13

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