Nature Search

High-speed fixed-target serial virus crystallography

A new sample-delivery method for serial X-ray crystallography exploits the full repetition rate of the X-ray free-electron laser at the LCLS facility, thus enabling efficient, high-speed data collection to solve the three-dimensional structures of viruses.

Philip Roedig
Helen M Ginn
Alke Meents
Research19 Jun 2017
Nature Methods

Volume: 14, P: 805-810
SARS-CoV-2 M^pro responds to oxidation by forming disulfide and NOS/SONOS bonds

The main protease, a key enzyme of SARS-CoV-2, can protect itself from oxidative damage. Here, Reinke, Schubert, and colleagues used XFEL radiation to image the enzyme, revealing the disulfide and NOS/SONOS bonds that form in response to oxygen.

Patrick Y. A. Reinke
Robin Schubert
Thomas J. Lane
ResearchOpen Access07 May 2024
Nature Communications

Volume: 15, P: 1-10
Pink-beam serial crystallography

Serial X-ray crystallography (SX) is used for data collection at X-ray Free Electron Lasers. Here the authors show that a polychromatic “pink” synchrotron X-ray beam can be used for SX, which is useful when crystal supply is limited and will allow time-resolved measurements at synchrotron sources in the future.

A. Meents
M. O. Wiedorn
H. N. Chapman
ResearchOpen Access03 Nov 2017
Nature Communications

Volume: 8, P: 1-12
Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene

The structures of amyloid fibres are currently primarily studied through solid state NMR and cryo-EM. Here the authors present a free-standing graphene support device that allows diffraction imaging of non-crystalline amyloid fibrils with single X-ray pulses from an X-ray free-electron laser.

Carolin Seuring
Kartik Ayyer
Henry N. Chapman
ResearchOpen Access09 May 2018
Nature Communications

Volume: 9, P: 1-10
Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections

Reinke et. al. show that targeting host proteins like cathepsins is a promising strategy for treating SARS-CoV-2 and other viral infections due to their mutational stability in contrast to highly mutable viral targets.

Patrick Y. A. Reinke
Edmarcia Elisa de Souza
Alke Meents
ResearchOpen Access18 Oct 2023
Communications Biology

Volume: 6, P: 1-13
High numerical aperture multilayer Laue lenses

Andrew J. Morgan
Mauro Prasciolu
Saša Bajt
ResearchOpen Access01 Jun 2015
Scientific Reports

Volume: 5, P: 1-14
Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease

Three natural phenolic compounds are found to bind to an allosteric site in SARS-CoV-2 papain-like protease and exhibit antiviral activity in vitro, showing potential as starting scaffolds for drug design.

Vasundara Srinivasan
Hévila Brognaro
Christian Betzel
ResearchOpen Access11 Aug 2022
Communications Biology

Volume: 5, P: 1-12
Localising functionalised gold-nanoparticles in murine spinal cords by X-ray fluorescence imaging and background-reduction through spatial filtering for human-sized objects

Florian Grüner
Florian Blumendorf
Christoph Hoeschen
ResearchOpen Access08 Nov 2018
Scientific Reports

Volume: 8, P: 1-12
Multimodal X-ray imaging of nanocontainer-treated macrophages and calcium distribution in the perilacunar bone matrix

Karolina Stachnik
Martin Warmer
Alke Meents
ResearchOpen Access04 Feb 2020
Scientific Reports

Volume: 10, P: 1-9
A micro-patterned silicon chip as sample holder for macromolecular crystallography experiments with minimal background scattering

P. Roedig
I. Vartiainen
A. Meents
ResearchOpen Access29 May 2015
Scientific Reports

Volume: 5, P: 1-11
X-ray focusing with efficient high-NA multilayer Laue lenses

Saša Bajt
Mauro Prasciolu
Christian E Hamm
ResearchOpen Access26 Nov 2017
Light: Science & Applications

Volume: 7, P: 17162

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