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Showing 1–3 of 3 results
Advanced filters: Author: Allie Lipshutz Clear advanced filters

  • Tissue-resident macrophages (TRM) are important mediators of local immunity. Here the authors show that the deficiency or inhibition of a kinase, WNK1, unlinks macrophage colony-stimulating factor signaling and resulted macropinocytosis with the downstream, potentially IRF8-mediated genetic program to bias progenitor differentiation to neutrophil instead of TRM.

    • Alissa J. Trzeciak
    • Zong-Lin Liu
    • Justin S. A. Perry
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Saavedra et al. show that broad-spectrum antibiotics impair homeostatic efferocytosis of macrophages in mice by affecting the gut microbiota. Microbial butyrate is shown to rescue homeostatic efferocytosis efficiency in vivo.

    • Pedro H. V. Saavedra
    • Alissa J. Trzeciak
    • Justin S. A. Perry
    Research
    Nature Metabolism
    Volume: 6, P: 1682-1694