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Showing 1–2 of 2 results
Advanced filters: Author: Allison Wolder Clear advanced filters

  • Engineering enzymes to utilize the noncanonical redox cofactors such as nicotinamide mononucleotide (NMN + ) is challenging. Here, the authors report a growth-based selection platform for NMN + -reducing enzyme engineering and show its application in developing a phosphite dehydrogenase with improved catalytic efficiency.

    • Linyue Zhang
    • Edward King
    • Han Li
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Flavin-based biocatalysis using flavin mononucleotide (FMN) cofactor attracts significant attention for its application in asymmetric alkene reduction and various other reactions, however, the scale-up of flavin-based biocatalysis in flow remains unexplored. Here, the authors develop a closed-loop flow platform for H2-driven regeneration of cofactor FMNH2 and ene-reduction using immobilized Old Yellow Enzyme, achieving >99% conversion of ketoisophorone to levodione.

    • Guiyeoul Lim
    • Donato Calabrese
    • Lars Lauterbach
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-7