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Showing 1–4 of 4 results
Advanced filters: Author: Almudena Serrano-Benitez Clear advanced filters

  • CRISPR-based genetic screens are providing new insights into the consequences of deficiencies in DNA damage response and repair pathways. These include insights into the regulation of homologous recombination and of replication stress and their crosstalk with other repair pathways, into novel cancer therapies and into the basis of cancer-drug resistance.

    • Samah W. Awwad
    • Almudena Serrano-Benitez
    • Stephen P. Jackson
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 24, P: 477-494

  • The ATM kinase is a key regulator of the DNA damage response to double-strand breaks (DSBs) and its homozygous loss in patients predisposes to lymphoid malignancies. Here, the authors develop a Tdp2−/− Atm−/− double-deficient mouse model to uncover topoisomerase II-induced DSBs as significant drivers of the genomic rearrangements that underpin these tumours.

    • Alejandro Álvarez-Quilón
    • José Terrón-Bautista
    • Felipe Cortés-Ledesma
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • The role of ATM in DNA double-strand break (DSB) signalling is well established, but its function in the repair process remains controversial. Here, Álvarez-Quilón et al.show that ATM acts in the joining of blocked DSBs, uncovering DNA end structure as a key factor determining ATM involvement in DSB repair.

    • Alejandro Álvarez-Quilón
    • Almudena Serrano-Benítez
    • Felipe Cortés-Ledesma
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-10