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Showing 1–10 of 10 results
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  • Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

    • Dami A. Collier
    • Anna De Marco
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 593, P: 136-141

  • The spike protein of the Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 than Delta, and a marked change in its antigenicity increases Omicron’s evasion of therapeutic and vaccine-elicited neutralizing antibodies.

    • Bo Meng
    • Adam Abdullahi
    • Ravindra K. Gupta
    ResearchOpen Access
    Nature
    Volume: 603, P: 706-714

  • A study of SARS-CoV-2 variants examining their transmission, infectivity, and potential resistance to therapies provides insights into the biology of the Delta variant and its role in the global pandemic.

    • Petra Mlcochova
    • Steven A. Kemp
    • Ravindra K. Gupta
    ResearchOpen Access
    Nature
    Volume: 599, P: 114-119

  • Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

    • Steven A. Kemp
    • Dami A. Collier
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 592, P: 277-282

  • Individuals over eighty years of age are less likely to mount a good immune response against SARS-CoV-2 (measured by neutralization titres) after the first dose of the BNT162b2 mRNA vaccine, but achieve good neutralization after the second dose.

    • Dami A. Collier
    • Isabella A. T. M. Ferreira
    • Ravindra K. Gupta
    ResearchOpen Access
    Nature
    Volume: 596, P: 417-422

  • Transcriptomic and proteomic profiling of blood samples from individuals with COVID-19 reveals immune cell and hematopoietic progenitor cell alterations that are differentially associated with disease severity.

    • Emily Stephenson
    • Gary Reynolds
    • Muzlifah Haniffa
    ResearchOpen Access
    Nature Medicine
    Volume: 27, P: 904-916

  • The SARS-CoV-2 spike glycoprotein is flexible, and its receptor-binding domain (RBD) fluctuates between open and closed conformations. Disulfide bonds are engineered into the spike ectodomain to lock the RBD in the closed state, leading to a construct with high thermostability.

    • Xiaoli Xiong
    • Kun Qu
    • John A. G. Briggs
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 934-941

  • Ruffieux, Hess and colleagues analyze longitudinal phenotyping of patients with coronavirus disease 2019 to show that covariation of innate immune cell numbers, kynurenine metabolites and lipid metabolites influence the restoration of homeostasis, the risk of death and that of long COVID.

    • Hélène Ruffieux
    • Aimee L. Hanson
    • Christoph Hess
    ResearchOpen Access
    Nature Immunology
    Volume: 24, P: 349-358