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Showing 1–3 of 3 results
Advanced filters: Author: Altaira D. Dearborn Clear advanced filters

  • Cryo-electron microscopy structures of apolipoprotein B100 (apoB100) in complex with the LDL receptor (LDLR) provide insight into binding interfaces and explain how mutations in apoB100 or in LDLR can give rise to familial hypercholesterolaemia.

    • Mart Reimund
    • Altaira D. Dearborn
    • Joseph Marcotrigiano
    Research
    Nature
    Volume: 638, P: 829-835

  • Crystal structures of the hepatitis C virus (HCV) glycoprotein E2 in complex with CD81 reveal the conformational changes that occur in E2 after binding of CD81 and the effects of pH on binding affinity.

    • Ashish Kumar
    • Reafa A. Hossain
    • Joseph Marcotrigiano
    Research
    Nature
    Volume: 598, P: 521-525

  • Hepatitis C virus (HCV) uses a hybrid entry mechanism. Upon exposure to low pH, envelope glycoprotein E2 releases an internal loop into the host membrane. Here we show the amino terminal region is a critical determinant for membrane interaction, providing insights into the HCV entry mechanism.

    • Ashish Kumar
    • Tiana C. Rohe
    • Joseph Marcotrigiano
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10