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Showing 1–3 of 3 results
Advanced filters: Author: Alvin Gogineni Clear advanced filters

  • It has been previously shown that combining immune checkpoint inhibitors with TGFβ blockade potentiates anti-tumor immune responses. Here the authors show that, in an immune excluded preclinical tumor model, combining therapeutic anti-PD-L1 with anti-TGFβ treatment promotes expansion and differentiation of stem-cell like CD8 + T cells.

    • Alessandra Castiglioni
    • Yagai Yang
    • Sören Müller
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Lymph nodes expand after an inflammatory challenge to accommodate their increased cellularity. Turley and colleagues show that fibroblastic reticular cells regulate this expansion process through the interaction of podoplanin with its receptor CLEC-2 expressed on incoming dendritic cells.

    • Jillian L Astarita
    • Viviana Cremasco
    • Shannon J Turley
    Research
    Nature Immunology
    Volume: 16, P: 75-84

  • AhYoung, Eckard et al. show that the expression of Neutrophil Serine Protease 4 (NSP4) during the early stages of mast cell development regulates the levels of histamine and serotonin in mast cell granules. This study reveals an important physiological function of NSP4 in mast cell-mediated vascular leakage in mice, establishing NSP4 as a potential therapeutic target for mast cell-dependent immune disorders.

    • Andrew P. AhYoung
    • Sterling C. Eckard
    • Menno van Lookeren Campagne
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-13