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Showing 1–11 of 11 results
Advanced filters: Author: Alvin P. Makohon-Moore Clear advanced filters

  • Comparison of multiple lesions from individual pancreases sheds light on how ancestral clones can spread through the ductal system and give rise to precursor lesions, with acquisition of further mutations leading to pancreatic cancer.

    • Alvin P. Makohon-Moore
    • Karen Matsukuma
    • Christine A. Iacobuzio-Donahue
    Research
    Nature
    Volume: 561, P: 201-205

  • Christine Iacobuzio-Donahue and colleagues report a detailed analysis of whole-genome sequencing data from primary and metastatic tumors in four patients with pancreatic cancer. They find that in each patient primary tumors and metastases have identical mutations in known driver genes.

    • Alvin P Makohon-Moore
    • Ming Zhang
    • Christine A Iacobuzio-Donahue
    Research
    Nature Genetics
    Volume: 49, P: 358-366

  • Implementing high-throughput single-cell DNA sequencing for the study of solid tumours has been challenging. Here, the authors present an optimised approach for snap-frozen tissue single nuclei extraction and DNA sequencing, which can be applied to study pancreatic ductal adenocarcinoma evolution and heterogeneity.

    • Haochen Zhang
    • Elias-Ramzey Karnoub
    • Christine A. Iacobuzio-Donahue
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • In pancreatic cancer the Kras and Trp53 transgene driven KPC mouse model is used to experimentally study disease processes. Here, the authors analyse tumour evolution within the KPC model, finding both linear and branched evolution and highlighting the utility of this model in mechanistic research of tumour evolution.

    • Noushin Niknafs
    • Yi Zhong
    • Rachel Karchin
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • In multiple myeloma, disease progresses via seeding to different anatomic sites and clonal expansion. Here, utilising autopsy material, the authors show that systemic seeding accelerates at relapse following treatment.

    • Heather J. Landau
    • Venkata Yellapantula
    • Francesco Maura
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Tumours frequently metastasize to multiple anatomical sites and understanding how these different metastases evolve may be important for therapy. Here, the authors develop a method—Treeomics—that can construct phylogenies from multiple metastases from next-generation sequencing data.

    • Johannes G. Reiter
    • Alvin P. Makohon-Moore
    • Martin A. Nowak
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Andrew Feinberg, Christine Iacobuzio-Donahue and colleagues describe the epigenomic reprogramming that occurs during pancreatic cancer progression. They also show that hematogenous metastases co-evolve a dependence on the oxidative branch of the pentose phosphate pathway (oxPPP) and that oxPPP inhibition reverses chromatin reprogramming and blocks tumorigenic potential.

    • Oliver G McDonald
    • Xin Li
    • Andrew P Feinberg
    Research
    Nature Genetics
    Volume: 49, P: 367-376

  • This Analysis article examines the extent of genetic heterogeneity within several types of untreated cancers, with particular regard to its clinical relevance, and finds that the homogeneity of predicted functional mutations in driver genes is the rule rather than the exception.

    • Johannes G. Reiter
    • Marina Baretti
    • Bert Vogelstein
    Research
    Nature Reviews Cancer
    Volume: 19, P: 639-650