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Actin nucleation by WH2 domains at the autophagosome

Autophagy is a catabolic process whereby cellular components are degraded by the autophagosome, but the role of the actin cytoskeleton is not clear. Here Coutts and La Thangue show that the actin nucleator JMY is recruited to the autophagosome via binding LC3, and promotes actin nucleation that is required for autophagosome maturation.

Amanda S. Coutts
Nicholas B. La Thangue
ResearchOpen Access30 Jul 2015
Nature Communications

Volume: 6, P: 1-9
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality

Calorie burning is normally turned off in thermogenic brown fat at warm temperatures. Here the authors show that adipocyte oxygen sensing directly boosts brown fat calorie burning, even at warm temperatures.

Rongling Wang
Mario Gomez Salazar
Zoi Michailidou
ResearchOpen Access29 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Functional interplay between E2F7 and ribosomal rRNA gene transcription regulates protein synthesis

Amanda S Coutts
Shonagh Munro
Nicholas B La Thangue
ResearchOpen Access14 May 2018
Cell Death & Disease

Volume: 9, P: 1-9
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs

Dysregulation of ribonucleoprotein complex granules, previously implicated in neuromuscular disease, can drive pathogenesis in a genetic form of dilated cardiomyopathy, as shown in gene-edited pigs and patient-derived cardiomyocytes.

Jay W. Schneider
Saji Oommen
Janell K. Fox
Research13 Nov 2020
Nature Medicine

Volume: 26, P: 1788-1800
Author Correction: Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs

Jay W. Schneider
Saji Oommen
Janell K. Fox
Amendments and Corrections02 Jun 2021
Nature Medicine

Volume: 27, P: 1309
p53-dependent DNA repair during the DNA damage response requires actin nucleation by JMY

Ignacio Rodriguez-Pastrana
Eleni Birli
Amanda S. Coutts
ResearchOpen Access04 May 2023
Cell Death & Differentiation

Volume: 30, P: 1636-1647
p53-cofactor JMY is a multifunctional actin nucleation factor

JMY, originally discovered as a binding partner of the p53 co-activator p300, is an actin-nucleating protein, assembling filaments both by activation of the Arp2/3 complex and through an Arp2/3-independent mechanism.

J. Bradley Zuchero
Amanda S. Coutts
R. Dyche Mullins
Research15 Mar 2009
Nature Cell Biology

Volume: 11, P: 451-459
PARP1 mediated PARylation contributes to myogenic progression and glucocorticoid transcriptional response

Arnold Tan
Awais Z. Younis
Craig L. Doig
ResearchOpen Access22 Apr 2023
Cell Death Discovery

Volume: 9, P: 1-13

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Actin nucleation by WH2 domains at the autophagosome

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Mapping the human genetic architecture of COVID-19

A second update on mapping the human genetic architecture of COVID-19

Whole-genome sequencing reveals host factors underlying critical COVID-19

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality

Adeno-associated virus 2 infection in children with non-A–E hepatitis

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Functional interplay between E2F7 and ribosomal rRNA gene transcription regulates protein synthesis

Genomic investigations of unexplained acute hepatitis in children

Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs

Author Correction: Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs

p53-dependent DNA repair during the DNA damage response requires actin nucleation by JMY

p53-cofactor JMY is a multifunctional actin nucleation factor

PARP1 mediated PARylation contributes to myogenic progression and glucocorticoid transcriptional response

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