Rugema, Garland-Kuntz et al. report the 2.7 Å crystal structure of a fragment of a catalytically active PLCε in which the RA1 domain is integrated into the core. They find that a conserved amphipathic helix in the autoregulatory X–Y linker of PLCε modulates its catalytic activity in cells. This study provides structural insights into the regulation of this essential cardiovascular enzyme.
- Ngango Y. Rugema
- Elisabeth E. Garland-Kuntz
- Angeline M. Lyon
