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Showing 1–7 of 7 results
Advanced filters: Author: Amanda L Marzo Clear advanced filters
  • CD8+ T cells primed in the absence of CD4+ T cell help fail to develop a robust memory cell response. Zloza et al. now report that these CD4-unhelped CD8+ T cells can be rescued by activating their cell surface receptor NKG2D, which restores CD8+ T cell expansion and cytolytic activity during a recall response and protection in a mouse model of influenza infection.

    • Andrew Zloza
    • Frederick J Kohlhapp
    • José A Guevara-Patiño
    Research
    Nature Medicine
    Volume: 18, P: 422-428
  • How are different memory T-cell subsets related? This is a topic of much debate; but in this article, it is suggested that the central memory and effector memory CD8+T cells that are generated after an acute infection are distinct cell lineages.

    • Leo Lefrançois
    • Amanda L. Marzo
    Reviews
    Nature Reviews Immunology
    Volume: 6, P: 618-623
  • An international consortium reports the genomic sequence for ten Drosophila species, and compares them to two other previously published Drosophila species. These data are invaluable for drawing evolutionary conclusions across an entire phylogeny of species at once.

    • Andrew G. Clark
    • Michael B. Eisen
    • Iain MacCallum
    Research
    Nature
    Volume: 450, P: 203-218
  • XMRV was identified in samples isolated from prostate cancer tissues in 2006, but has since been shown to have arisen from the genetic recombination of two viral genomes carried in the germ-line DNA of mice. Here, Sfanos et al. chart the rise and fall of XMRV from its initial detection in 2006, via claims of its role in prostate cancer, to the 2011 report of its recombinant origin, and explain why they believe XMRV has no role in prostate cancer pathogenesis.

    • Karen S. Sfanos
    • Amanda L. Aloia
    • Alan Rein
    Reviews
    Nature Reviews Urology
    Volume: 9, P: 111-118