Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–16 of 16 results
Advanced filters: Author: Amanda Nourse Clear advanced filters

  • A whole-genome sequencing analysis of 100 pancreatic ductal adenocarcinomas has discovered known and newly identified genetic drivers of pancreatic cancer; these genetic alterations can be classified into four subtypes, which raises the possibility of improved targeting of clinical treatments.

    • Nicola Waddell
    • Marina Pajic
    • Sean M. Grimmond
    Research
    Nature
    Volume: 518, P: 495-501

  • Exome sequencing and copy number analysis are used to define genomic aberrations in early sporadic pancreatic ductal adenocarcinoma; among the findings are mutations in genes involved in chromatin modification and DNA damage repair, and frequent and diverse somatic aberrations in genes known as embryonic regulators of axon guidance.

    • Andrew V. Biankin
    • Nicola Waddell
    • Sean M. Grimmond
    Research
    Nature
    Volume: 491, P: 399-405

  • Kelch-domain KLHDCX E3 ligases bind substrate C-terminal glycines. This study reveals substrate selectivity by E3s with similar structures; C-degrons are perceived by a “C-terminus anchor motif”, whose display on different Kelch propeller blades along with distal interactions establish specificity.

    • Daniel C. Scott
    • Sagar Chittori
    • Brenda A. Schulman
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Cryo-electron microscopy, nuclear magnetic resonance and X-ray crystallography are used to provide structural and mechanistic details of the activation of anaplastic lymphoma kinase by the ligands ALKAL1 and ALKAL2.

    • Andrey V. Reshetnyak
    • Paolo Rossi
    • Charalampos G. Kalodimos
    Research
    Nature
    Volume: 600, P: 153-157

  • The genomes of 102 primary pancreatic neuroendocrine tumours have been sequenced, revealing mutations in genes with functions such as chromatin remodelling, DNA damage repair, mTOR activation and telomere maintenance, and a greater-than-expected contribution from germ line mutations.

    • Aldo Scarpa
    • David K. Chang
    • Sean M. Grimmond
    Research
    Nature
    Volume: 543, P: 65-71

  • The nucleolus is a membrane-less organelle formed through liquid–liquid phase separation (LLPS). Here the authors use biophysical methods and show that the nucleolar protein nucleophosmin (NPM1) also undergoes LLPS through homotypic, inter-NPM1 interactions and discuss implications for the ribosome biogenesis process.

    • Diana M. Mitrea
    • Jaclyn A. Cika
    • Richard W. Kriwacki
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • APC/C is an E3 ligase complex of ~1.5 MDa that regulates cell division. APC/CCDH1 is inhibited during interphase by EMI1. Now, NMR spectroscopy, electron microscopy and enzymology analyses are integrated, revealing that EMI1's 143-residue C-terminal domain binds distinct regions of APC/CCDH1 to block the substrate-binding site and inhibit ubiquitin-chain elongation.

    • Jeremiah J Frye
    • Nicholas G Brown
    • Brenda A Schulman
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 827-835

  • An integrated genomic analysis of 456 human pancreatic ductal adenocarcinomas identifies four subtypes defined by transcriptional expression profiles and show that these are associated with distinct histopathological characteristics and differential prognosis.

    • Peter Bailey
    • David K. Chang
    • Sean M. Grimmond
    Research
    Nature
    Volume: 531, P: 47-52

  • When the proapoptotic effector proteins BAX and BAK bind the BH3 domain of BID or BIM, they undergo conformational changes and oligomerization followed by insertion into the mitochondrial outer membranes, which leads to their permeabilization and, eventually, apoptosis. The NMR structure of the human BID BH3–BAK complex now provides structural insight into BAK activation.

    • Tudor Moldoveanu
    • Christy R Grace
    • Douglas R Green
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 589-597

  • ABCC4 is a chemotherapeutic drug exporter highly expressed in acute myeloid leukemia. Here, the authors demonstrate that MPP1 anchors ABCC4 to the outer cell membrane mediating drug resistance in leukemic cells and identify antimycin A as a chemical probe that disrupts such interaction and restores sensitivity.

    • Aaron Pitre
    • Yubin Ge
    • John D. Schuetz
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • π-stacking interactions unique between residues of PUMA and Bcl-xL, which lead to the unfolding of Bcl-xL via an allosteric mechanism, are required to disrupt p53–Bcl-xL interaction and induce apoptosis. This is the first example of regulated protein unfolding for signal transmission.

    • Ariele Viacava Follis
    • Jerry E Chipuk
    • Richard W Kriwacki
    Research
    Nature Chemical Biology
    Volume: 9, P: 163-168

  • An in vivo transposon screen in a pancreatic cancer model identifies frequent inactivation of Usp9x; deletion of Usp9x cooperates with KrasG12D to accelerate rapidly pancreatic tumorigenesis in mice, validating their genetic interaction.

    • Pedro A. Pérez-Mancera
    • Alistair G. Rust
    • David A. Tuveson
    Research
    Nature
    Volume: 486, P: 266-270