The authors show that chronic treatment with antipsychotic drugs decreases expression of mGlu2 and histone acetylation at its promoter in frontal cortex. This is mediated through 5-HT2A receptor–dependent upregulation of HDAC2. HDAC inhibitors prevent this decrease in mGluR2, augmenting the behavioral effects of antipsychotics.
- Mitsumasa Kurita
- Terrell Holloway
- Javier González-Maeso
