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Showing 1–4 of 4 results
Advanced filters: Author: Amin S. Ghabrial Clear advanced filters

  • Seamless tubes are found in Drosophila tracheal terminal cells, but it is still unclear how they grow. Ghabrial and colleagues find that the small GTPase Rab35, and its apically localized GAP, Whacked, direct tube shape and growth. They also highlight a role for dynein in this process.

    • Jodi Schottenfeld-Roames
    • Amin S. Ghabrial
    Research
    Nature Cell Biology
    Volume: 14, P: 386-393

  • Most organs are composed of tubes of differing cellular architectures, including intracellular 'seamless' tubes. Two studies examining the morphogenesis of the seamless tubes formed by the excretory canal cell in Caenorhabditis elegans reveal a previously unappreciated role for osmoregulation of tubulogenesis: hyperosmotic shock recruits canalicular vesicles to the lumenal membrane to promote seamless tube growth.

    • Jodi Schottenfeld-Roames
    • Amin S. Ghabrial
    News & Views
    Nature Cell Biology
    Volume: 15, P: 137-139

  • Genetic mosaic analysis in Drosophila melanogaster shows that there are two classes of cells in the budding tracheal branches: those that migrate to the tip, and those that follow these lead cells and form a tube. The position of the cell results from competition within the population, with those expressing the highest level of FGF taking the lead positions at the tip, and the others forming the branch stalk.

    • Amin S. Ghabrial
    • Mark A. Krasnow
    Research
    Nature
    Volume: 441, P: 746-749